They conclude, “In the absence of higher-level evidence to support the universal use of tranexamic acid for all patients with severe TBI, the data suggest that tranexamic acid should be used judiciously in the prehospital setting. The data do not suggest abandoning the current practice of using tranexamic acid in those patients with extracranial injuries and substantial blood loss. However, in patients with isolated severe TBI, tranexamic acid administration seems detrimental to survival.”
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