![](https://www.acepnow.com/wp-content/uploads/2022/09/serum-sickness-graphic-642x336.png)
Summary
Removal of the offending agent is important. There are very limited data evaluating the efficacy of corticosteroid treatment for serum sickness-like reactions. While emergency physicians often treat SSLR with corticosteroids, we were only able to find a single study that examined this treatment and it showed no significant difference.
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ACEP Now: Vol 41 – No 09 – September 2022Dr. Jones is assistant professor of pediatric emergency medicine at the University of Kentucky in Lexington.
Dr. Cantor is professor of emergency medicine and pediatrics, director of the pediatric emergency department, and medical director of the Central New York Regional Poison Control Center at Upstate Medical University in Syracuse, New York.
References
- Del Pozzo-Magana BR, Abuzgaia A, Murray B et al. Pediatric serum sickness-like reaction: A 10-year retrospective cohort study. Paediatr Child Health. 2021; 26(7):428-435.
- Heelan K, Shear NH. Cutaneous drug reactions in children: An update. Pediatr Drugs. 2013; 15(6):493-503.
- Parshuram CS, Phillips RJ, Nash MC. Serum sickness in a paediatric emergency department: The role of cefaclor. J Paediatr Child Health. 1999; 35(2):223-4.
- Joubert GI, Hadad K, Matsui D et al. Selection of treatment of cefaclor-associated urticarial, serum sickness-like reactions and erythema multiform by emergency pediatricians: Lack of a uniform standard of care. Can J Clin Pharmacy. 1999; 6(4):197-201.
- Yorulmaz A, Akin F, Sert A et al. Demographic and clinical characteristics of patients with serum-sickness-like reaction. Clin Reumatol. 2018 May; 37(5):1389-94.
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